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Individual research data requirements and EPA-approved tests for Conventional, Biochemical, and Microbial pesticide end-use products.
| Adapted from EPA Data Requirements for Development and Registration of Pesticide End-Use Products (EPs) • Prepared by Cynthia Ann Smith of Conn & Smith, Inc. • 1/31-25 | |||||
|---|---|---|---|---|---|
| Conventional | |||||
| RD - Registration Division | BPPD - Biopesticides Division, unique tests for biopesticides, applicable to Biochemical and Microbial) | REGISTRATION | EXPERIMENTAL USE PERMIT | ||
| Test Guideline Series # | Required (R), Conditionally Required (CR), Not Required (NR) | FOOD USE* (Tolerance Requirement) | FOOD USE* (Tolerance Requirement) | NON-FOOD USE | |
| RD | BPPD | TEST/GUIDLINE NAME | Conventional | ||
| Applicator Exposure (Occupational & Residential) | |||||
| 875.1100 | Dermal Outdoor Exposure | R | R | R | |
| 875.1300 | Inhalation Outdoor Exposure | R | R | R | |
| 875.1500 | Biological Monitoring | CR | CR | CR | |
| 875.1600 | Data Reporting and Calculations | R | R | R | |
| 875.1700 | Product Use Information | R | R | R | |
| Confidential Product Chemistry | |||||
| 830.1550 | Product Identity and Composition | R | NR | NR | |
| 830.1600 | Description of Materials Used to Produce the Product | R | NR | NR | |
| 830.1620 | Description of Production Process | R | NR | NR | |
| 830.1650 | Description of formulation process | R | R | R | |
| 830.1670 | Discussion of Formation of Impurities | R | R | R | |
| 830.1700 | Preliminary Analysis | CR | CR | CR | |
| 830.1750 | Certified Limits | R | NR | NR | |
| 830.1800 | Enforcement Analytical Method | R | NR | NR | |
| 830.1900 | Submittal of Samples | CR | R | R | |
| Ecological Effects (Aquatic Non-target Organisms) | |||||
| 850.1010 | Aquatic Invertebrate, Acute Toxicity, Freshwater | R | R | R | |
| 850.1025 | Oyster Acute Toxicity Test (Shell Deposition) | R (minimum 1 mollusk, 1 other invertebrate) | R | R | |
| 850.1035 | Mysid Acute Toxicity Test | R | R | ||
| 850.1045 | Penaeid Acute Toxicity Test | R | R | ||
| 850.1055 | Bivalve Acute Toxicity Test (Embryo, Larval) | R | R | ||
| 850.1075 | Fish Acute Toxicity Test: Freshwater | R | R | R | |
| 850.1950 | Simulated or Actual Field Testing for Aquatic Organisms | CR | CR | CR | |
| 850.1075 | Fish Acute Toxicity Test: Marine | R | R | R | |
| Ecological Effects (Non-target Birds, Bees, Plants) | |||||
| 850.2500 | Simulated or Actual Field Testing | CR | CR | CR | |
| 850.3030 | Honey Bee Toxicity of Residues on Foliage | CR | CR | CR | |
| 850.3040 | Field Testing for Pollinators | CR | CR | CR | |
| 850.4100 | Terrestrial Plant Toxicity: Seedling Emergence | CR | CR | CR | |
| 850.4150 | Terrestrial Plant Toxicity: Vegetative Vigor | CR | CR | CR | |
| 850.4300 | Terrestrial Field Phytotoxicity | CR | CR | CR | |
| 850.4450 | Aquatic Field Phytotoxicity | CR | CR | CR | |
| Environmental Fate | |||||
| 835.6100 | Terrestrial Field Dissipation | CR | NR | NR | |
| 835.6200 | Aquatic (Sediment) Field Dissipation | R | NR | NR | |
| 835.6400 | Combination and Tank Mix Field Dissipation | CR | NR | NR | |
| Mammalian Toxicology Data | |||||
| 870.1100 | Acute Oral Toxicity | R | R | R | |
| 870.1200 | Acute Dermal Toxicity | R | R | R | |
| 870.1300 | Acute Inhalation Toxicity | R | R | R | |
| 870.2400 | Acute Eye Irritation | R | R | R | |
| 870.2500 | Acute Dermal Irritation | R | R | R | |
| 870.2600 | Skin Sensitization | R | R | R | |
| 870.3200 | 21/28 Day Dermal | R | NR | NR | |
| 870.3250 | 90-Day Dermal | CR | NR | NR | |
| Physical & Chemical Properties | |||||
| 830.6302 | Color | R | R | R | |
| 830.6303 | Physical State | R | R | R | |
| 830.6304 | Odor | R | R | R | |
| 830.6313 | Stability to Normal and Elevated Temperatures, Metals, and Metal Ions | R | R | R | |
| 830.6314 | Oxidation/Reduction: Chemical Incompatibility | CR | CR | CR | |
| 830.6315 | Flammability | CR | CR | CR | |
| 830.6316 | Explodability | CR | CR | CR | |
| 830.6317 | Storage Stability | R | R | R | |
| 830.6319 | Miscibility | CR | CR | CR | |
| 830.6320 | Corrosion Characteristics | R | R | R | |
| 830.6321 | Dielectric Breakdown Voltage | CR | CR | CR | |
| 830.7000 | pH | CR | R | R | |
| 830.7100 | Viscocity | CR | CR | CR | |
| 830.7300 | Density / Relative Density / Bulk Density | R | R | R | |
| 830.7520 | Particle Size, Fiber Length, and Diameter Distribution | CR | CR | CR | |
| Post-Application Exposure (Occupational & Residential) | |||||
| 875.2100 | Dislodgeable Foliar Residue and Turf Transferable Residues | R | R | R | |
| 875.2200 | Soil Residue Dissipation | R | R | R | |
| 875.2400 | Dermal Exposure | R | R | R | |
| 875.2500 | Inhalation Exposure | R | R | R | |
| 875.2600 | Biological Monitoring | CR | CR | CR | |
| 875.2700 | Product Use Information | R | R | R | |
| 875.2800 | Description of Human Activity | R | R | R | |
| 875.2900 | Data Reporting and Calculations | R | R | R | |
| 875.3000 | Nondietary Ingestion Exposure | R | R | R | |
| Residue Chemistry | |||||
| 860.1200 | Directions for Use | R | R | NR | |
| 860.1380 | Magnitude of the Residue: Storage Stability Data | R | R | NR | |
| 860.1400 | Magnitude of the Residue: Water, Fish, Potable Water, and Irrigated Crops | R | R | NR | |
| 860.1480 | Magnitude of the Residue: Meat, Milk, Poultry, Eggs | CR | CR | NR | |
| 860.1500 | Magnitude of the Residue: Crop Field Trials (Plants) | R | R | NR | |
| 860.1520 | Magnitude of the Residue: Processed Food/Feed | CR | CR | NR | |
| 860.1550 | Proposed Tolerance | R | R | NR | |
| 860.1560 | Reasonable Grounds in Support of the Petition | R | R | NR | |
| 860.1900 | Field Rotational Crops | CR | CR | NR | |
| Spray Drift | |||||
| 840.1100 | Droplet Size | CR | CR | CR | |
| 840.1200 | Droplet Size | CR | CR | CR | |
| Adapted from EPA Data Requirements for Development and Registration of Pesticide End-Use Products (EPs) • Prepared by Cynthia Ann Smith of Conn & Smith, Inc. • 1/31-25 | |||||
|---|---|---|---|---|---|
| Biochemical | |||||
| RD - Registration Division | BPPD - Biopesticides Division, unique tests for biopesticides, applicable to Biochemical and Microbial) | REGISTRATION | EXPERIMENTAL USE PERMIT | ||
| Test Guideline Series # | Required (R), Conditionally Required (CR), Not Required (NR) | FOOD USE* (Tolerance Requirement) | FOOD USE* (Tolerance Requirement) | NON-FOOD USE | |
| RD | BPPD | TEST/GUIDLINE NAME | Biochemical | ||
| Confidential Product Chemistry | |||||
| 880.1100 | Product Identity and Composition | R | R | R | |
| 880.1200 | Description of Materials Used to Produce the Product | R | R | R | |
| 880.1200 | Description of Production Process | R | R | R | |
| 880.1200 | Description of formulation process | R | R | R | |
| 880.1400 | Discussion of Formation of Impurities | R | R | R | |
| 830.1700 | Preliminary Analysis | CR | CR | CR | |
| 830.1750 | Certified Limits | R | R | R | |
| 830.1800 | Enforcement Analytical Method | R | R | R | |
| 830.1900 | Submittal of Samples | CR | CR | CR | |
| Ecological Effects (Aquatic Non-target) | |||||
| 850.1010 | Aquatic Invertebrate, Acute Toxicity, Freshwater | R | R | R | |
| 850.1025 | Oyster Acute Toxicity Test (Shell Deposition) | CR (Tier III) | NR | NR | |
| 850.1035 | Mysid Acute Toxicity Test | CR (Tier III) | NR | NR | |
| 850.1045 | Penaeid Acute Toxicity Test | CR (Tier III) | NR | NR | |
| 850.1055 | Bivalve Acute Toxicity Test (Embryo, Larval) | CR (Tier III) | NR | NR | |
| 850.1075 | Fish Acute Toxicity Test: Freshwater | R | R | R | |
| 850.1950 | Simulated or Actual Field Testing for Aquatic Organisms | CR (Tier III) | NR | NR | |
| 850.1075 | Fish Acute Toxicity Test: Marine | CR (Tier III) | NR | NR | |
| Ecological Effects (Non-target Birds, Bees, Plants) | |||||
| 850.2100 | Avian Acute Oral Toxicity | R | R | R | |
| 850.2200 | Avian Dietary Toxicity | R | R | R | |
| 850.3040 | Field Testing for Pollinators | CR (Tier III) | NR | NR | |
| 850.4100 | Terrestrial Plant Toxicity: Seedling Emergence | R | NR | NR | |
| 850.4150 | Terrestrial Plant Toxicity: Vegetative Vigor | R | NR | NR | |
| Mammalian Toxicology Data | |||||
| 870.1100 | Acute Oral Toxicity | R | R | R | |
| 870.1200 | Acute Dermal Toxicity | R | R | R | |
| 870.1300 | Acute Inhalation Toxicity | R | R | R | |
| 870.2400 | Acute Eye Irritation | R | R | R | |
| 870.2500 | Acute Dermal Irritation | R | R | R | |
| 870.2600 | Skin Sensitization | R | R | R | |
| Physical & Chemical Properties | |||||
| 830.6303 | Physical State | R | R | R | |
| 830.6315 | Flammability | CR | CR | CR | |
| 830.6317 | Storage Stability | R | R | R | |
| 830.6319 | Miscibility | CR | CR | CR | |
| 830.6320 | Corrosion Characteristics | R | R | R | |
| 830.7000 | pH | CR | CR | CR | |
| 830.7100 | Viscocity | CR | CR | CR | |
| 830.7300 | Density / Relative Density / Bulk Density | R | R | R | |
| 830.7520 | Particle Size, Fiber Length, and Diameter Distribution | CR | CR | CR | |
| Residue Chemistry | |||||
| 860.1200 | Directions for Use | R | R | NR | |
| 885.2400 | Magnitude of the Residue: Storage Stability Data | CR | CR | NR | |
| 885.2600 | Magnitude of the Residue: Water, Fish, Potable Water, and Irrigated Crops | CR | R | NR | |
| 885.2500 | Magnitude of the Residue: Crop Field Trials (Plants) | CR | CR | NR | |
| 860.1520 | Magnitude of the Residue: Processed Food/Feed | CR | CR | NR | |
| 860.1550 | Proposed Tolerance | CR | CR | NR | |
| 860.1560 | Reasonable Grounds in Support of the Petition | CR | CR | NR | |
| Adapted from EPA Data Requirements for Development and Registration of Pesticide End-Use Products (EPs) • Prepared by Cynthia Ann Smith of Conn & Smith, Inc. • 1/31-25 | |||||
|---|---|---|---|---|---|
| Microbial | |||||
| RD - Registration Division | BPPD - Biopesticides Division, unique tests for biopesticides, applicable to Biochemical and Microbial) | REGISTRATION | EXPERIMENTAL USE PERMIT | ||
| Test Guideline Series # | Required (R), Conditionally Required (CR), Not Required (NR) | FOOD USE* (Tolerance Requirement) | FOOD USE* (Tolerance Requirement) | NON-FOOD USE | |
| RD | BPPD | TEST/GUIDLINE NAME | Microbial | ||
| Confidential Microbiology | |||||
| 885.1400 | Analysis of Samples | R | R | R | |
| 885.1500 | Certification of Limits | R | R | R | |
| 885.1300 | Discussion of Formation of Unintentional Ingredients | R | R | R | |
| 885.1200 | Manufacturing Process | R | R | R | |
| 885.1100 | Product Identity | R | R | R | |
| Ecological Effects (Non-target Birds, Bees, Plants) | |||||
| 850.2500 | Simulated or Actual Field Testing | CR (Tier IV) | NR | NR | |
| Mammalian Toxicology Data | |||||
| 870.1100 | Acute Oral Toxicity | R | R | R | |
| 870.1200 | Acute Dermal Toxicity | R | R | R | |
| 870.1300 | Acute Inhalation Toxicity | R | R | R | |
| 870.2400 | Acute Eye Irritation | R | R | R | |
| 870.2500 | Acute Dermal Irritation | R | NR | NR | |
| 885.3400 | Hypersensitivity Incidents | R | R | R | |
| Microbial: Tier 1 | |||||
| 885.4300 | Nontarget Plant Testing | CR | NR | NR | |
| Physical & Chemical Properties | |||||
| 830.6317 | Storage Stability | R | R | R | |
| 830.6319 | Miscibility | R | R | R | |
| 830.6320 | Corrosion Characteristics | R | R | R | |
| 830.7100 | Viscocity | R | R | R | |
| Residue Chemistry | |||||
| 860.1200 | Directions for Use | R | R | NR | |
| 885.2400 | Magnitude of the Residue: Storage Stability Data | CR | CR | NR | |
| 885.2600 | Magnitude of the Residue: Water, Fish, Potable Water, and Irrigated Crops | CR | CR | NR | |
| 885.2550 | Magnitude of the Residue: Meat, Milk, Poultry, Eggs | CR | CR | NR | |
| 885.2500 | Magnitude of the Residue: Crop Field Trials (Plants) | CR | CR | NR | |
| 885.2100 | Chemical identity | CR | CR | NR | |
| 885.2500 | Nature of the Residue in Animals | CR | CR | NR | |
| 885.2200 | Nature of the Residue in Plants | CR | CR | NR | |
*Note: “FOOD USE” does not necessarily mean a pesticide product that will be used directly on food products. Pesticides used in such a manner where residues may collect (establishing the need for a tolerance) on food products or organisms harvested for food would be classified as “FOOD USE.”
Efficacy Data (Series 810 - Product Performance Test Guidelines) is required for all pesticide types and registration situations, but tests will vary depending on the product's intended performance as described in the label directions.
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